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Student Research


In 2017 Welch summer research programSummer Research Program

Advisors:  Drs. Paul Pyenta and Hyunshun Shin

Drs. Shin and Pyenta worked jointly with all 4 students:
Alisa Rasley & Haley Shepard tested synthesized HDAC inhibitors for use as anti-cancer agents modeled after SAHA in MCF-7 and MDA-MB-231 breast cancer cell lines. Bethany Everett and Ananda Lewis synthesized Potential Anti-Cancer Drugs targeting Histone Deacetylases

Advisors:  Drs. Paul Pyenta and Hyunshun ShinHaley Shepard

Haley Shepard tested synthesized HDAC inhibitors for use as anti-cancer agents modeled after SAHA in MCF-7 and MDA-MB-231 breast cancer cell lines.

Advisors:  Drs. Paul Pyenta and Hyunshun ShinBethany Everett

Bethany Everett worked on creating a HDACi that interferes with the HAT/HDAC enzymatic activity in cancer cells.

Advisors:  Drs. Paul Pyenta and Hyunshun ShinAlisa Rasley

Alisa Rasley tested synthesized HDAC inhibitors for use as anti-cancer agents modeled after SAHA in MCF-7 and MDA-MB-231 breast cancer cell lines.

Advisors:  Drs. Paul Pyenta and Hyunshun ShinAnanda Lewis

Ananda Lewis designed and synthesized HDACs Inhibitors as Anticancer Agents

Megan ButlerMegan Butler

2017 Summer Research

advisor:  Dr. Donnay

 Megan synthesized a new chromium polypyridyl complex and made progress towards an analogue of the DPPZ ligand that might allow metal complexes to bind better to DNA for possible use in photodynamic therapy.

In 2016 Welch summer research programSummer Research Program

Advisors:  Drs. Paul Pyenta and Hyunshun Shin

Drs. Paul Pyenta and Hyunshun Shin worked jointly with all 5 students:  Genna Hart and Ananda Lewis worked on discovery of new bioactive compounds from extracts of West Texas Plants.   Mukundwa Gael, George Gutierrez and Shantel Thomas synthesized new histone deacetylase inhibitors, followed by evaluating breast cancer cell viability with them in breast cancer MCF-7 and MDA-MB-231 cell lines for potential anticancer agents.

Advisors:  Drs. Paul Pyenta and Hyunshun ShinMukundwa Gael

Left:  Mukundwa Gael synthesized histone deacetylase inhibitors, followed by evaluating breast cancer cell viability with them in breast cancer MCF-7 and MDA-MB-231 cell lines for potential anticancer agents.

Right: Genna Hart worked on discovery of new bioactive compounds from extracts of West Texas Plants.  

Advisors:  Drs. Paul Pyenta and Hyunshun ShinGeorge Gutierrez

George Gutierrez (left) synthesized new histone deacetylase inhibitors.

Welch Summer2015 Welch  Summer Research Program in Shinlab

Dialfin HammondDialfin Hammond worked on discovery of antibiotics from natural products; Coreopsis tinctoria and Matela reticulate.

Kara BlackUnder Dr. Shin 2014, Kara Black  worked on developing the screening method for antimicrobial activities with West Texas Plants.

Genna HartDr. Shin 2015, Genna Hart worked on extracting from Ambrosia artemisifolia
and Monarda didyma grown in West Texas. 

Daniel KentDr. Shin 2015: Daniel Kent worked on synthesizing new histone deacetylase inhibitors, followed by evaluating enzyme inhibitory activities and cell viability.

Lucy RashiwalaDr. Shin 2015, Lucy Rashiwala worked on discovery of new anticancer agents targeting histone deacetylase 1 and 8. 

Lizbet MillerUnder Dr. Shin 2015, Lizbet Miller research on designing and synthesizing bioactive substances against cancer cells.

Ralph CadetResearch with Dr. Donnay 2015; Ralph Cadet worked on synthesizing bromine and nitro substituted analogs of the ligand dipyridophenazene (DPPZ).


Parker CoyleParker Coyle
2014 Summer Research
advisor: Dr. Shin

Parker’s research project is to develop new synthetic methods using FirstMate Synthesizer toward Histone Deacetylase Inhibitors. Parker


Sophie Southwell Sophie Southwell
2014 Summer Research
advisor: Dr. Donnay

"Sophie synthesized a new bridging ligand."


C. Stephen Anyasor
C. Stephen Anyasor
2014 Summer Research
advisor: Dr. Donnay

"Stephen made progress towards new intercalating ligands."


Damon Rose Damon Rose

2013 & 2014 Summer Research
advisor: Dr. Shin

Damon’s research projects are to develop the purication methods of organic compounds, and to synthesize novel hydroxamic acid derivatives for potential anticancer drugs.


Sara PloetzSara Ploetz

2012 Summer Research
advisor: Dr. Shin

Synthesis of New Inhibitors of Histone deacetylases


Staci Marie PalaciosStaci Marie Palacios

2012 Summer Research
advisor: Dr. Shin

Staci Palacios synthesized beta-lactamase inhibitors for potential antibiotics.


Christi BarrChristi Barr
2012 & 2013 summer
advisor: Dr. Donnay

Christi modified a ligand to increase the emission intensity of the resulting chromium complex.


Josh BrooksJosh Brooks
2012 & 2013 summer
advisor: Dr. Donnay

Josh worked on making new ligands and a bridging chromium compound.
Josh Brooks


Amanda GenzlingAmanda Genzling

2011 & 2012 summer
advisor: Dr. Shin

The project is a continuation of the project begun by Heather Whitehead, designing and synthesizing other inhibitors of ornithine decarboxylase.
Amanda Genzling


Toyosi AdewunmiToyosi Adewunmi

2011 & 2012 summer
advisor: Dr. Donnay

Toyosi worked to find a way to separate various chromium compounds using the HPLC. She also developed procedures to determine how well these complexes bind to DNA.


Tara WiliamsTara Williams

2011 summer
Advisor: Dr. Shin

Tara is focusing on polyamine synthesis and finding inhibitors of the enzymes in the polyamine biosynthetic pathway.


Nathan Worley
Nathan Worley
2010 & 2011 summer
Advisor: Dr. Donnay

This project involves the synthesis and characterization of compounds containing chromium and polypyridyl ligands.


Jonathan Urbanczyk
Jonathan Urbanczyk
2010 & 2011 summer
advisors: Dr. Shin and Dr. Donnay

This project is a joint project between Dr. Donnay and Dr. Shin. It involves the design and synthesis of small molecules that target a wide range of Gram-negative bacteria.
Jonathan Urbanczyk
Heather Whitehead and Erica Rawls
2009 & 2010 summer
advisor: Dr. Shin


Heather Whitehead and Erica RawlsHeather Whitehead and Erica Rawls

Heather worked to design and synthesize an inhibitor of ornithine decarboxylase.


Brad HenryBrad Henry

2009 & 2010 summer
advisor: Dr. Pyenta

Design optimization of GFP-encoding vector for inducible expression in bacillus thuringensis; compatible promoters and regulatory sequences.


Matthew DurhamMatthew Durham

2008 & 2007 summer
advisor: Dr. Pyenta

two projects:

1. Design of a GFP-encoding vector compatible for transfection into Bacillus Thuringiensis.

2. Investigation of antibody IgG structure in solution using FRET analysis.
Matthew


Tim FliegelTim Fliegel

2007 summer
advisor: Dr. Donnay
2006 summer
advisor: Dr. Jeffery

Tim worked with Dr. Donnay to synthesize a ligand which could be used to make self-assembled monolayers.
Tim


Madeline ManningMadeline Manning

2007 summer
advisor: Dr. Pyenta

Design of a GFP-encoding vector compatible for transfection into Bacillus Thuringiensis.
Madeline


Len KimLen Kim

2006 summer
advisor: Dr. Pyenta

Liquid chromatography analysis of fluorescently tagged IgE.
Len_Kim


Catrina ReedCatrina Reed

2005 & 2006 summer
advisor: Dr. Pyenta

Dr. Pyenta and I are working on fluorescently tagging a bacterium by transfecting GFP plasmids into the bacterium's own genetic code through electroporation. The bacterium, Bacillus Thuringiensis, is a bioinsecticide that that produces a delta-endotoxin during sporulation which is toxic to some insects. If successful, we will be able to track the bacterium through the intestinal tract of various insects and test its effectiveness as a bioinsecticide.
2005_Catrina


Eric PalmerEric Palmer

2005 summer
advisor: Dr. Pyenta

I am doing research in fluorescence resonance energy transfer (FRET) of monoclonal antibodies. To determine size and conformation of these antibodies, namely IgG, would be beneficial both to the pharmaceutical and academia world. Most of this research thus far has been trying to develop improved fluorescencent probes through conjugation of previously untested pairs. Hopefully, the new probes will lead to a further in-depth look into the structure and functionalities of IgG.
2005_Eric


Jessica CrawfordJessica Crawford

2004 summer
advisor: Dr. Jeffery

Synthesis of a Double-Headed Nucleoside through Knoevenagel/Aldol Pathway
2004_Jessica


Jennifer CoddingJennifer Codding

2004 summer
advisor: Dr. Jeffery

Synthesis of a novel carbohydrate toward Double-Headed Nucleosides: via Grignard Reagent
2004_Jennifer


Zana and JenniferZana & Jennifer

2002 summer
advisor: Dr. Jeffery

-working with the NMR
2002_zana